Our research aims to reduce the burden of these diseases for individuals and society. We approach this broad scientific vision through a range of research designs and traditions. We are lead center for the Osteoarthritis Policy Model (PI Dr. Losina), a computer simulation model of the natural history and outcome of knee osteoarthritis.  The model has enabled us to perform policy relevant and innovative research on such diverse topics as the cost effectiveness of osteoarthritis prevention and treatment strategies including obesity management, injury prevention and total knee replacement; the potential cost effectiveness of disease modifying osteoarthritis drugs (DMOADs); and the total economic and quality of life burden of knee osteoarthritis in the US.

We also are the Coordinating Center for the MeTeOR Trial (Meniscal Tear in Osteoarthritis Research; PI Dr. Katz), a seven center NIH funded randomized controlled trial of arthroscopic partial meniscectomy in patients with meniscal tear and osteoarthritis. This RCT addresses one of the key questions in the management of patients with knee pain: is arthroscopic partial meniscectomy superior to a rigorous PT regimen in patients with OS and symptomatic meniscal tear?  We shall find out. In addition to these two projects we lead several other NIH supported research and training programs. Dr. Katz is the Program Director and Dr. Losina is the Director of the Methodology Core of the Brigham and Women’s Multidisciplinary Clinical Research Center (MCRC), a NIAMS P60 grant program. One of the projects in the P60 program, directed by Dr. Katz, is the most comprehensive study of the determinants of revision of total hip arthroplasty ever undertaken.  We direct a NIAMS funded T32 pre and postdoctoral clinical research training program for musculoskeletal research. Under Dr. Losina’s direction, we provide methodologic expertise for modeling, cohort and clinical trial studies of HIV prevention, natural history and management.

We coordinate the PRIDE program in the Department of Orthopedic Surgery at BWH (Program for Research Incubation and Development). This program enables Orthopedic Department faculty to collaborate with OrACORe personnel to move their clinical research ideas forward. OrACORe faculty and staff typically provide expertise in design, data management, data analysis and interpretation on PRIDE projects.

We invite you to explore our myriad studies and programs currently active here at OrACORe.