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Project status: Active, conducting four-year follow-up with cohort.

An estimated 14 million people in the United States have symptomatic osteoarthritis of the knees. Currently, there are no medications that can stop or reverse the damage due to osteoarthritis. We hope to better understand how osteoarthritis of the knee changes over time and how it affects the lives of patients so that we can help guide new therapies to treat osteoarthritis. With these goals in mind, we have started a registry of patients with knee osteoarthritis called ORBIT (Osteoarthritis Registry of Biomarkers and Imaging Trajectories).

We are currently enrolling 100 subjects with symptomatic and radiographic knee arthritis. These patients come in for a baseline visit and one-year follow-up visit that each include bio-sample collection, bilateral knee MRIs, bilateral knee x-rays, a musculoskeletal exam of the strength and range of motion in the knee, and a questionnaire that assesses knee symptoms and other medical and psychosocial variables.

This project is supported by Biosplice Therapeutics.


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